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Investigators
Debby Tsuang, M.D., M.Sc.
Education
Institution and Location
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Degree, if applicable
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Year(s)
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Field of Study |
University of Iowa, Iowa City, IA
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B.S.
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1983
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Psychology |
University of Iowa College of Medicine, Iowa City, IA
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M.D.
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1987
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Medicine |
University of Iowa College of Medicine, Iowa City, IA
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M.Sc.
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1992
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Epidemiology |
| University of Iowa |
Resident Physician |
1992 |
Psychiatry |
| Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System |
Resident Physician |
1995 |
Geriatric Psychiatry |
| University of Washington School of Medicine |
Resident Physician |
1995 |
Medical Genetics |
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A. Positions and Honors
Positions and Employment
1993-1995 |
Acting Instructor, Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
1995-1999 |
Acting Assistant Professor, Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
1995-1999 |
Acting Assistant Professor, Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
1995-2004 |
Adjunct Assistant Professor, Dept Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA |
1999-2004 |
Assistant Professor Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
2001- |
Member, Seattle Institute for Biomedical and Clinical Research, Seattle, WA |
2004-2009 |
Associate Professor, Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
2004-2009 |
Adjunct Associate Professor, Dept Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA |
2007-2009 |
Adjunct Associate Professor, Div of Medical Genetics, Dept of Internal Medicine, University of Washington School of Medicine, Seattle, WA |
2009- |
Professor, Dept of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA |
2009- |
Adjunct Professor, Div of Medical Genetics, Dept of Internal Medicine, University of Washington School of Medicine, Seattle, WA |
2009- |
Adjunct Professor, Department of Epidemiology, University of Washington School of Medicine, Seattle, WA |
2011- |
Director, VISN-20 Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA |
Other Experience and Professional Memberships
2006-2009 |
Review Committee Member, NIMH Behavioral Genetics and Epidemiology Study Section |
2006-2009 |
Program Planning Committee Member, Society of Biological Psychiatry |
2007- |
Editorial Board, Am J Med Genet (Neuropsychiatric Section) |
2006- |
Executive Steering Committee, Behavioral Neuroscience Group, VAPSHCS |
2006- |
Committee Member, Dept of Psychiatry Research Task Force, University of Washington |
2009- |
Committee Member, Scientific Review Committee, R&D, VAPSHCS |
Honors
1980-1983 |
Dean's List, Wheaton College & University of Iowa |
1992 |
APA/Dista Product Resident Research Award |
1992 |
Second Prize, Winokur Resident Research Award |
1994 |
Eagles Award for Alzheimer's Research |
1995 |
Geriatric Academic Training Award |
2001-2002 |
Browning Foundation Investigator |
B. Selected peer-reviewed publications (in chronological order).
Coryell W, Tsuang D. Hypothalamic-pituitary-adrenal axis hyperactivity and psychosis: recovery during an 8-year follow-up. Am J Psychiatry 149:1033-1039, 1992.
Tsuang D, Coryell W. An 8-year follow-up of patients with DSM-III-R psychotic depression, schizoaffective disorder, and schizophrenia. Am J Psychiatry 150:1182-1888, 1993.
Tsuang D, Kukull W, Sheppard L, Barnhart R, Peskind E, Edland S, Schellenberg G, Raskind M, Larson E. Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer’s disease samples. J Am Geriatr Soc 44:704-707, 1996.
Tsuang D, Raskind MA, Leverenz J, Peskind ER, Schellenberg G, Bird TD. The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biol Psychiatry 41:191-195, 1997.
Levy-Lahad E, Tsuang D, Bird TD. Recent advances in the genetics of Alzheimer’s disease. J Geriatr Psychiatry Neurol 11:42-54, 1998.
Tsuang D, DiGiacomo L, Lipe H, Bird TD. Familial aggregation of schizophrenia-like symptoms in Huntington’s disease. Am J Med Genet (Neuropsychiatry Section) 81:323-327, 1998.
Faraone SV, Tsuang MT, Tsuang DW. Genetics of mental disorders: What practitioners and students need to know. New York: Guilford Press, 1999.
Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind E, Raskind M, Larson E. Clinico-neuropathological correlation of Alzheimer’s disease in a community-based case series. J Am Geriatr Soc 47:564-569, 1999.
Tsuang D, Larson EB, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz J, Peskind ER, Lim A, Raskind M, Thompson ML, Mirra S, Gearing M, Schellenberg G, Kukull W. The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer’s disease in a community-based case series. Arch Neurol 56:1489-1495, 1999.
Tsuang D, Almqvist E, Lipe H, Strgar F, DiGiacomo L, Hoff D, Eugenio C, Hayden MR, Bird TD. Familial aggregation of psychotic symptoms in Huntington's disease. Am J Psychiatry 157:1955-1959, 2000.
Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto R, Craig U, Chapman N, Anderson L, Bird T, Plato C, Perl D, Weiderholt W, Galasko D, Schellenberg G. TAU as a susceptibility gene for amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam. Arch Neurol 58:1871-1878, 2001.
Tsuang D, Skol A, Faraone S, Bingham S, Young K, Prabhudesai S, Haverstock S, Mena F, Menon AS, Bisset D, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Boehnke M, Schellenberg G, Tsuang M. Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet (Neuropsychiatric Section) 105:662-668, 2001.
Faraone S, Skol A, Tsuang D, Bingham S, Young K, Prabhudesai S, Haverstock S, Mena F, Menon AS, Bisset D, Pepple J, Sautter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Tsuang M, Schellenberg G. Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample. Am J Med Genet (Neuropsychiatric Section) 114:598-604, 2002.
Tsuang D, Bird T. Genetics of dementia. Medical Clinics of North America 86:591-614, 2002.
Tsuang D, Dalan A, Eugenio C, Poorkaj P, Limprasert P, La Spada AR, Steinbart E, Bird T, Leverenz J. Familial dementia with Lewy bodies: a clinical and neuropathological study of 2 families. Arch Neurol 59:1622-1630, 20
Tsuang DW, Faraone SV, Tsuang MT. Implications of genetics and the use of genetic counseling. Directions in Psychiatry 22:155-164, 2002.
Faraone SV, Tsuang D, Tsuang MT. Methods in psychiatric genetics. In Tsuang M, Tohen M. Textbook in Psychiatric Epidemiology, Second edition. New York: John Wiley & Sons, 2002.
Bonner L, Tsuang D, Cherrier M, Eugenio C, Du J, Steinbart E, Limprasert P, La Spada A, Seltzer B, Bird T, Leverenz J. Familial dementia with Lewy bodies with an atypical clinical presentation. J Geriatr Psychiatry Neurol 16:59-64, 2003.
Skol AD, Young KA, Tsuang DW, Faraone SV, Haverstock SL, Bingham S, Prabhudesai S, Mena F, Menon AS, Yu CE, Rundell P, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Schellenberg GD, Tsuang MT. Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet (Neuropsychiatric Section) 118B:8-15, 2003.
Tsuang D, Faraone SV, Tsuang MT. The role of genetic counseling. In Stone WS, Faraone SV, Tsuang MT. Early Clinical Intervention and Prevention in Schizophrenia. Totowa: Humana Press, 2004.
Tsuang D, Bird T. Genetics of dementia. In Sadavoy J, Jarvik L, Grossberg G, Meyers B. Comprehensive Textbook of Geriatric Psychiatry, Third edition. New York: W.W. Norton and Company, 2004.
Tsuang D, Bird T. Genetics of dementia. In Sadavoy J, Jarvik L, Grossberg G, Meyers B. Comprehensive Textbook of Geriatric Psychiatry, Third edition. New York: W.W. Norton and Company, 2004.
Peskind ER, Tsuang DW, Bonner LT, Pascualy M, Riekse RG Snowden MB, Thomas R, Raskind MA. Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study. Alzheimer Dis Assoc Disord 19:23-28, 2005.
Skol AD, Xiao R, Boehnek M, Veterans Affairs Cooperative Study #366 Investigators (Tsuang D). An algorithm to construct genetically similar subsets of families with the use of self-reported ethnicity information. Am J Hum Genet 77:346-354, 2005.
Faraone SV, Skol AD, Tsuang DW, Young KA, Haverstock SL, Prabhudesai S, Mena F, Menon AS, LeongL, Sautter F, Baldwin C, Bingham S, Weiss D, Collins J, Keith T, Vanden Eng JL, Boehnke M, Tsuang MT,Schellenberg GD. Genome scan of schizophrenia families in a large Veterans Affairs Cooperative Studysample: Evidence for linkage to 18p11.32 and for racial heterogeneity on chromosomes 6 and 14. Am J Med Genet (Neuropsychiatric Section) 139B:91-100, 2005.
Tsuang DW, Wilson RK, Lopez OL, Luedecking-Zimmer EK, Leverenz JB, DeKosky ST, Kamboh MI,Hamilton RL. Genetic association between the APOE E4 allele and Lewy bodies in Alzheimer disease.Neurology 64:509-513, 2005.
Calkins ME, Dobie DJ, Cadenhead KS, Olincy A, Freedman R, Green MF, Greenwood TA, Gur RE, LightGA, Mintz J, Nuechterlein KH, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR,Tsuang DW, Tsuang MT, Turetsky BI, Braff DL. The Consortium on the Genetics of Endophenotypes in Schizophrenia (COGS): Model recruitment, assessment, and endophenotyping methods for a multi-site collaboration. Schiz Bull 33:33-48, 2007.
Greenwood TA, Braff DL, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RE, Light GA, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Schork NJ. Initial Heritability Analyses of Endophenotypic Measures for Schizophrenia: The Consortium on the Genetics of Schizophrenia (COGS). Arch Gen Psych, 64:1242-1250, 2007.
Turetsky B, Greenwood T, Olincy A, Radant A, Braff D, Cadenhead K, Dobie D, Freedman R, Green M,Gur R, Gur R, Light G, Mintz J, Nuechterlein K, Schork N, Seidman S, Siever L, Silverman J, Stone W, Swerdlow S, Tsuang D, Tsuang M, Calkins M. Abnormal auditory N100 amplitude: Heritable endophenotypes in first-degree relatives of schizophrenia probands. Biol Psychiatry 64:1051-1059, 2008.
Jun G, Schellenberg GS, Alzheimer's Disease Genetics Consortium (member Tsuang D).Meta-Analysis confirms CR1, CLU, and PICALM as Alzheimer’s disease risk loci and reveals interactionswith APOE genotypes. Arch Neurol 67:1473-1484, 2010.
12. Mata IF, Shi M, Agarwal P, Chang KA, Edwards KL, Factor SA, Galasko DR, Ginghina C, Griffith A, Higgins DS, Kay DM, Kim H, Leverenz JB, Quinn JF, Roberts JW, Samii A, Snapinn KW, Tsuang D, Yearout D, Zhang J, Payami H, Zabetian. A SNCA variant associated with Parkinson’s Disease and plasma a-synuclein level. Arch Neurol 67:1350-1356, 2010.
Radant A, Dobie D, Calkins M, Olincy A, Braff D, Cadenhead K, Freedman R, Green N, Greenwood T, Gur R, Gur R, Light G, Meichle S, Millard S, Mintz J, Nuechterlein K, Schork N, Seidman L, Siever L, Silverman J, Stone W, Swerdlow N, Tsuang M, Turetsky B, Tsuang D. Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: Data from the COGS study. Psychophysiology 47(5):846-856, 2010
Tsuang D, Millard SP, Ely B, Chi P, Wang K, Raskind, WH, Brkanac Z, Yu CE. The effect of algorithm on copy number variation detection. PLoS ONE, 5(12):e14456, 2010.
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